Abietane Diterpenoids from <i>Perovskia atriplicifolia</i> and Their Anti‐<scp>HBV</scp> Activities

Abstract

Bioassay‐guided phytochemical investigation on the 90% EtOH extract of Perovskia atriplicifolia resulted in the isolation of eight abietane diterpenoids, including three new ones ( 1–3 ). Based on spectroscopic methods involving 1D and 2D NMR spectroscopy techniques, mass spectrometry, and optical rotation, the structures of the new compounds ( 1–3 ) were unambiguously characterized. Compounds 1–2 and 4–8 were evaluated for their anti‐ HBV (hepatitis B virus) activity in HepG 2.2.15 cell line. Results suggested rosmadial ( 8 ) had the most anti‐ HBV potency, suppressing the secretion of HBsAg and HBeAg, with IC 50 values of 0.09 and 0.34 mM , respectively.