Total Synthesis of Pyridovericin:  Studies toward the Biomimetic Synthesis of Pyridomacrolidin

Abstract

[reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.