Indium-Mediated Allylation and Propargylation of Isatins: A Facile Synthesis of 3-Substituted 3-Hydroxyoxindoles - Concepedia

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Indium-Mediated Allylation and Propargylation of Isatins: A Facile Synthesis of 3-Substituted 3-Hydroxyoxindoles

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References

2003

Year

Vijay Nair, Sindu Ros, C. N. Jayan, S. Viji

Enantioselective SynthesisEngineeringIndium-mediated AllylationFacile SynthesisSodium IodideOrganic Chemistry3-Substituted 3-HydroxyoxindolesAllyl/propargyl BromideChemistryPharmacologySynthetic ChemistryCorresponding 3-Substituted 3-HydroxyoxindolesBiomolecular Engineering

Abstract

Isatins undergo efficient allylation/propargylation when reacted with allyl/propargyl bromide in the presence of indium and sodium iodide to afford the corresponding 3-substituted 3-hydroxyoxindoles.