Concepedia

DMAP Promoted Tandem Addition Reactions Forming Substituted Tetrahydroxanthones

Emmanuel B. Castillo‐Contreras, Gregory R. Dake

Organic Letters · 2014 · 26 citations · 44 references

DOI

Concepts

Abstract

Substituted tetrahydroxanthones are constructed using a DMAP-promoted tandem nucleophilic addition process. The reaction yields range from 39% to 73%. Disubstituted tetrahydroxanthones are generated as a ∼2.3:1 mixture of diastereomers favoring the formation of the trans-isomer.

References

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