Chirality · 2019 · 14 citations · 9 references
PharmacyChemistryMedicinal ChemistryAnalytical ChemistryDrug DiscoverySeparation ScienceChiral ChromatographyChiral SeparationChromatographic PurificationChromatographyStationary Phase ChemistrySupercritical Fluid ChromatographyChiral Supercritical Fluid ChromatographyDiscoveryEarly Drug DiscoveryImmobilized Chiral Stationary PhasesPreparative Chiral SeparationPreparative Separation ProcessesSupercritical Fluid Chiral ChromatographySupercritical Fluid Chiral Separation
Abstract Work from this paper details a novel walk‐up open‐access (OA) approach to enable chiral analytical method development and preparative separation of enantiomers in early discovery chemistry using supercritical fluid chromatography (SFC). We have demonstrated the success of this OA approach using immobilized chiral stationary phases (CSPs). After screening a diverse set of racemic drug candidates, we have concluded that a simplified OA chiral SFC platform can successfully purify approximately 60% of the analysed racemates. This streamlined OA workflow enables medicinal chemists with limited expertise in chiral method development to successfully and rapidly purify enantiomers for their projects using Waters UPC 2 and Prep100‐SFC instrumentation.
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