Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTKinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design StrategiesJack A. Bikker*, Natasja Brooijmans, Allan Wissner, and Tarek S. MansourView Author Information Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965* To whom correspondence should be addressed. Telephone: [phone]. Facsimile: 845 602 5682. E-mail: [email protected]Cite this: J. Med. Chem. 2009, 52, 6, 1493–1509Publication Date (Web):February 24, 2009Publication History Received22 August 2008Published online24 February 2009Published inissue 26 March 2009https://pubs.acs.org/doi/10.1021/jm8010542https://doi.org/10.1021/jm8010542review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views7894Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Drug resistance,Genetics,Inhibitors,Monomers,Peptides and proteins Get e-Alerts