Transgenic mice expressing IFN-gamma in the retina develop inflammation of the eye and photoreceptor loss.

Abstract

IFN-gamma alters the antigenic properties of intraocular tissue and induces intraocular inflammation in mice. The results suggest a key position of IFN-gamma in the development of pathologic conditions related to intraocular inflammation and provide a useful animal model for the further study of inflammatory disorders, including autoimmune diseases.