Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography

Abstract

PS-OCT enables accurate fibrosis detection and can distinguish tumor regions with low fibrosis. PS-OCT has significant potential for clinical impact, as the ability to differentiate tumor from fibrosis could be used to guide intraprocedural tissue sampling <i>in vivo</i>, or for rapid biopsy adequacy assessment <i>ex vivo</i>, to increase diagnostic tumor yield essential for patient care and research.