The neuroprotection of progesterone against Aβ-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes

A role for mitochondria in NLRP3 inflammasome activation

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Life Sciences, Cell Biology, Molecular Biology +12

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle, Veit Hornung, Gabor C. Petzold et al. · Nature Immunology · 2008 · 2.4K citations · Full text

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang et al. · Nature · 2008 · 2K citations

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Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Colin Dempsey, Karen Bryson, Orla M. Finucane et al. · Brain Behavior and Immunity · 2016 · 568 citations

Life Sciences, Neurobiology, Neuroscience +15