Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin

Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer

Roman Rouzier, Radhika Rajan, Peter J. Wagner et al. · Proceedings of the National Academy of Sciences · 2005 · 407 citations · Full text

Microtubule Disassembly by ATP-Dependent Oligomerization of the AAA Enzyme Katanin

James J. Hartman, Ronald D. Vale · Science · 1999 · 237 citations

Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation

Annapurna Vemu, Ewa Szczęsna, Elena A. Zehr et al. · Science · 2018 · 235 citations · Full text

Microtubule Architecture, Natural Sciences, Microtubule Arrays +11

Katanin spiral and ring structures shed light on power stroke for microtubule severing

Elena A. Zehr, Agnieszka Szyk, Grzegorz Piszczek et al. · Nature Structural & Molecular Biology · 2017 · 113 citations · Full text

Engineering, Microfabrication, Microtubule Severing +4

Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin

Pengfei Zhou, Yan Liu, Lu Zhou et al. · Journal of Medicinal Chemistry · 2016 · 86 citations

Compound 9, Chemical Biology, Combretastatin A-4 Binding +18