The Journal of Organic Chemistry · 2019 · 27 citations · 56 references
Natural SciencesChemistryMedicinal ChemistryCatalysisSynthetic Medicinal ChemistryCatalytic MaterialsCatalytic MechanismsRetrosynthetic AnalysisSulfur ChemistryChemoselective Bond CleavageCopper CatalysisCopper-catalyzed CouplingCopper-sulfur InteractionsElemental Sulfur ChemistryFunctional Group ToleranceOxidative Sulfur ChemistryTandem Catalysis
Copper-catalyzed aerobic oxidative sulfuration and annulation of propargylamines with elemental sulfur is described. The tandem reaction involves C-N bond cleavage and the formation of multiple C-S bonds, affording 1,2-dithiole-3-thiones in good to excellent yields with good functional group tolerance.
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