Resveratrol nano-capsule as an effi cient tool for blood pressure regulation: A study on metabolic syndrome induced mice

Abstract

Insulin resistance and overweight have been associated with major risk factors such as blood pressure (BP) for cardiovascular disease.In this study the effect of Nano-capsules of resveratrol (RV-NC) on BP control is evaluated.RV-NC nanoparticles were analyzed by SEM, Zeta sizer, Potentiometer and HPLC.The analysis resulted from RV-NC synthesis showed that the Nano capsules have characteristics such as size of 207 nm, zeta potential of -7.15 and loading effi ciency of 99.54% ± 1.02.BP reduction was associated with reduction of weight and enhance of QUICKI index which represents insulin resistance.RV-NC were prepared by interfacial deposition and then its applicability was evaluated in metabolic syndrome induces mice.The effect of RV-NC was studied on fourteen mice.Induction of syndrome by high fat diet and high BP was observed.The collected data were analyzed by ANOVA and Turkey criteria were used to compare the distinction between the groups.Finally, the results indicated that RV-NCtreated mice have regulated in systolic and diastolic blood pressure (compare to the other group (p< 0.05).The effective formulation of nano-capsules for resveratrol delivery not only can be helpful in increasing the in vivo stability, but also in regulation of the patient's blood pressure with at least cost of therapy.