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Publication | Open Access

Inhibiting BRAF Oncogene–Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair

DOIFull Paper Access

74

Citations

39

References

2019

Year

Ryan Robb, Linlin Yang, Changxian Shen, Adam R. Wolfe, Amy Webb, Xiaoli Zhang, Marall Vedaie, Motoyasu Saji, Sissy Jhiang, Matthew D. Ringel,
Clinical Cancer Research

Abstract

BRAF<sup>V600E</sup> mutation promotes NHEJ activity leading to radioresistance and BRAFi selectively radiosensitizes BRAF<sup>V600E</sup> thyroid cancer cells through inhibiting NHEJ. Our findings suggest that combining BRAFi and radiation may improve the therapeutic outcome of patients with BRAF<sup>V600E</sup>-mutant thyroid cancer.

References

YearCitations

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