Concepedia

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β <sub>1</sub> –induced collagen biosynthesis

Brintha Selvarajah, Ilan Azuelos, Manuela Platé, Delphine Guillotin, Ellen Forty, Greg Contento, Hannah V. Woodcock, Matthew Redding, Adam Taylor, Gino Brunori,

Science Signaling · 2019 · 171 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

-mTORC1-ATF4 axis may represent a novel therapeutic strategy for interfering with myofibroblast function in fibrosis and potentially in other conditions, including cancer.

References

43

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

Ganesh Raghu, Harold R. Collard, Jim Egan et al. · American Journal of Respiratory and Critical Care Medicine · 2011 · 7.3K citations · Full text

, , +17

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi, Roland M. du Bois, Ganesh Raghu et al. · New England Journal of Medicine · 2014 · 4.6K citations · Full text

, , +13

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Talmadge E. King, Williamson Z. Bradford, Socorro Castro-Bernardini et al. · New England Journal of Medicine · 2014 · 3.9K citations · Full text

, , +13

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Heather P. Harding, Yuhong Zhang, Huiquing Zeng et al. · Molecular Cell · 2003 · 3.3K citations · Full text

, , +12

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon et al. · Molecular Cell · 2010 · 2K citations · Full text

, , +13