Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Abstract

Surgical site infections (SSIs) are commonly caused by <i>Staphylococcus aureus</i> We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize <i>S. aureus</i> alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of <i>S. aureus</i> SSI. Therefore, monoclonal antibody-based neutralization of multiple <i>S. aureus</i> virulence factors may provide an adjunctive perioperative approach to combat <i>S. aureus</i> SSIs.