Concepedia

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Roger V. Ortines, Yu Wang, Haiyun Liu, Dustin Dikeman, Bret L. Pinsker, Robert J. Miller, Sophia E. Kim, Nicole E. Ackerman, Joe F. Rizkallah, LeeAnn T. Marcello,

Antimicrobial Agents and Chemotherapy · 2019 · 13 citations · 22 references

DOIFull text

Open access

Concepts

Abstract

Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus . We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI.

References

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