Concepedia

Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment

Lijun Wang, Chuanlong Guo, Xiuxue Li, Xuemin Yu, Xiangqian Li, Kuo Xu, Bo Jiang, Xiaoling Jia, Chao Li

European Journal of Medicinal Chemistry · 2019 · 40 citations · 45 references

DOI

Concepts

References

45

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

Anne‐Claude Gingras, Steven P. Gygi, Brian Raught et al. · Genes & Development · 1999 · 1.3K citations · Full text

, , +17

A hierarchy of ATP-consuming processes in mammalian cells

Frank Buttgereit, Martin D. Brand · Biochemical Journal · 1995 · 929 citations · Full text

, , +17

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Masahiro Morita, Simon‐Pierre Gravel, Valérie Chénard et al. · Cell Metabolism · 2013 · 838 citations · Full text

, , +13

Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G

Nathan J. Moerke, Hüseyin Aktaş, Han Chen et al. · Cell · 2007 · 570 citations · Full text

, , +14

eIF4E – from translation to transformation

Yaël Mamane, Emmanuel Petroulakis, Liwei Rong et al. · Oncogene · 2004 · 442 citations

, , +8