Concepedia

Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial

Fernando Bril, Diane Biernacki, Srilaxmi Kalavalapalli, Romina Lomonaco, Sreevidya Subbarayan, Jinping Lai, Fermin O. Tio, Amitabh Suman, Beverly Orsak, Joan Hecht,

Diabetes Care · 2019 · 302 citations · 26 references

DOI

Abstract

In this proof-of-concept study, combination therapy was better than placebo in improving liver histology in patients with NASH and T2DM. Vitamin E alone did not significantly change the primary histological outcome.

References

26

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

Journal of Hepatology · 2016 · 4.8K citations

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Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Arun J. Sanyal, Naga Chalasani, Kris V. Kowdley et al. · New England Journal of Medicine · 2010 · 3.2K citations · Full text

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

Eduardo Vilar‐Gómez, Yadina Martínez-Pérez, Luis Calzadilla Bertot et al. · Gastroenterology · 2015 · 2.3K citations · Full text

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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

Brent A. Neuschwander‐Tetri, Rohit Loomba, Arun J. Sanyal et al. · The Lancet · 2014 · 2.2K citations

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Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

Matthew J. Armstrong, Piers Gaunt, Guruprasad P. Aithal et al. · The Lancet · 2015 · 2K citations · Full text

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