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Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste

Stuart Smith, Betty Tyler, Toby Gould, Gareth J. Veal, Noah Gorelick, Jonathan Rowlinson, Riccardo Serra, Alison Ritchie, Philip Berry, Annette Otto,

Clinical Cancer Research · 2019 · 46 citations · 50 references

DOIFull text

Open access

Abstract

The significant survival benefit of intracavity chemotherapy demonstrates clinical applicability of PLGA/PEG paste-mediated delivery of temozolomide and etoposide adjuvant to radiotherapy. PLGA/PEG paste offers a future platform for combination delivery of molecular targeted compounds.

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