Concepedia

<i>SPOP</i> and <i>FOXA1</i> mutations are associated with PSA recurrence in <i>ERG</i> wt tumors, and <i>SPOP</i> downregulation with <i>ERG</i>‐rearranged prostate cancer

Silvia Hernández‐Llodrà, Laura Segalés, Ainara Safont, Núria Juanpere, Marta Lorenzo, Lluís Fumadó, Alejo Rodríguez‐Vida, Lluís Cecchini, Joaquim Bellmunt, Josep Lloreta

The Prostate · 2019 · 20 citations · 32 references

DOI

Abstract

In conclusion, SPOP and FOXA1 mutations may have prognostic value in ERG wt tumors. Interestingly, in absence of SPOP mutations, downregulation of this gene is a feature of many ERG-rearranged prostate tumors.

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