Do female age and body weight modify the effect of individualized <scp>FSH</scp> dosing in <scp>IVF</scp>/<scp>ICSI</scp> treatment? A secondary analysis of the <scp>OPTIMIST</scp> trial

Abstract

In women with a predicted hyper response undergoing IVF/ICSI treatment, female age and body weight seem to modify the effect of FSH dose individualization. Although a reduced FSH starting dose generally decreases the OHSS risks, it may also reduce the chance of a live birth, specifically for young women. Future studies could consider these findings when investigating the optimal approach to reduce OHSS risks while maintaining the probability of a live birth for predicted hyper responders in IVF/ICSI treatment.