Concepedia

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Enjie Liu, Qiuzhi Zhou, Ao‐Ji Xie, Mengzhu Li, Shujuan Zhang, He‐Zhou Huang, Zhen‐Yu Liuyang, Yali Wang, Bingjin Liu, Xiaoguang Li,

Translational Neurodegeneration · 2019 · 10 citations · 75 references

DOIFull text

Open access

Abstract

These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression.

References

75

Exercise training increases size of hippocampus and improves memory

Kirk I. Erickson, Michelle W. Voss, Ruchika Shaurya Prakash et al. · Proceedings of the National Academy of Sciences · 2011 · 4.6K citations · Full text

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More hippocampal neurons in adult mice living in an enriched environment

Gerd Kempermann, H. Georg Kuhn, Fred H. Gage · Nature · 1997 · 3.5K citations

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Aerobic Exercise Training Increases Brain Volume in Aging Humans

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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Nadia M. Tsankova, Olivier Berton, William Renthal et al. · Nature Neuroscience · 2006 · 1.7K citations

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