<i>In vitro</i> and <i>in vivo</i> evaluation of a novel mitomycin nanomicelle delivery system

Hongmei Yang, Miao Wang, Yihe Huang, Qiaoyu Qiao, Chunjie Zhao

RSC Advances · 2019 · 13 citations · 29 references

DOIFull text

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Concepts

Abstract

pharmacokinetics, tissue distribution and therapeutic study proved that PEG-FIbu/MMC micelles prolonged blood circulation, significantly improved the tumor accumulation and therapeutic efficacy, and reduced undesirable side effect on normal tissues compared to MMC injection. In general, PEG-FIbu/MMC micelles represented an effective strategy to improve the performance for the delivery of MMC and safety of medication.

References

29