Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

Tetsuya Mitsudomi, Satoshi Morita, Yasushi Yatabe et al. · The Lancet Oncology · 2009 · 4.1K citations

Medicine, Oncology, Pharmacology +15

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

Caicun Zhou, Yi‐Long Wu, Gongyan Chen et al. · The Lancet Oncology · 2011 · 4.1K citations

Medicine, Oncology, Pharmacology +10

EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization

Kathryn M. Ferguson, Mitchell B. Berger, Jeannine M. Mendrola et al. · Molecular Cell · 2003 · 812 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +5

Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile.

Susanne V. Allander, Nina N. Nupponen, Markus Ringnér et al. · PubMed · 2001 · 182 citations

Medicine, Molecular Biology, Oncology +17

Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells

Yoshinori Okabayashi, Yoshiaki Kido, Toshio Okutani et al. · Journal of Biological Chemistry · 1994 · 117 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17