Concepedia

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage

Alexander Götz, Nadine Mylonas, Philipp Högel, Mara Silber, Hannes Heinel, Simon Menig, Alexander Vogel, Hannes Feyrer, Daniel Huster, Burkhard Luy,

Biophysical Journal · 2019 · 42 citations · 90 references

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90

Scalable molecular dynamics with NAMD

J. C. Phillips, Rosemary Braun, Wei Wang et al. · Journal of Computational Chemistry · 2005 · 17.4K citations · Full text

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Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ<sub>1</sub> and χ<sub>2</sub> Dihedral Angles

Robert B. Best, Xiao Zhu, Jihyun Shim et al. · Journal of Chemical Theory and Computation · 2012 · 4.8K citations

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CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

Jumin Lee, Xi Cheng, Jason Swails et al. · Journal of Chemical Theory and Computation · 2015 · 4.3K citations · Full text

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A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

Katherine A. Henzler‐Wildman, Ming Lei, Vu Thai et al. · Nature · 2007 · 1.1K citations

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Reconstitution of γ-secretase activity

Dieter Edbauer, Edith Winkler, Jörg T. Regula et al. · Nature Cell Biology · 2003 · 875 citations

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