Membrane metalloprotease TRABD2A restricts HIV-1 progeny production in resting CD4+ T cells by degrading viral Gag polyprotein

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Cole Trapnell, Brian A. Williams, Geo Pertea et al. · Nature Biotechnology · 2010 · 16.1K citations

Developmental Biology, Functional Genomics, Rna Biology +10

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell et al. · Genome biology · 2013 · 13.4K citations · Full text

Bioinformatics, Gene Sequence Annotation, Natural Sciences +14

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

Cole Trapnell, Adam Roberts, Loyal A. Goff et al. · Nature Protocols · 2012 · 12.6K citations · Full text

Differential Gene, Natural Sciences, Genetics +11

Universal sample preparation method for proteome analysis

Jacek R. Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj et al. · Nature Methods · 2009 · 8.5K citations

Proteomic Technology, Biochemistry, Proteome Analysis +7

Differential analysis of gene regulation at transcript resolution with RNA-seq

Cole Trapnell, David G. Hendrickson, Martin Sauvageau et al. · Nature Biotechnology · 2012 · 3.7K citations · Full text

Bioinformatics, Natural Sciences, Genetics +10