Cardiac changes during the peri‐menopausal period in a VCD‐induced murine model of ovarian failure

Abstract

This is the first study to demonstrate remodelling of the heart in a model of peri-menopause, along with a disruption in ER-dependent regulation of the heart. These data indicate that oestrogen replacement therapy initiated after menopause affects a heart that is profoundly different from that found in reproductively intact animals.