Total synthesis of pseudouridine<i>via</i>Heck-type<i>C</i>-glycosylation

Abstract

Pseudouridine (<bold>1</bold>) was synthesized by functional group interconversions of the Heck adduct<bold>11</bold>from 2,4-dimethoxy-5-iodopyrimidine (<bold>8</bold>) and ribofuranoid glycal<bold>4</bold>.