Emerging infectious diseases · 2019 · 105 citations · 26 references
Veterinary MedicineInfectious DiseasesPediatricsInfectious Disease EpidemiologyPediatric Infectious DiseasesVirologyRespiratory InfectionsRespiratory Infectious DiseasesRespiratory Tract InfectionsSeasonal Transmission PatternsSeasonality In Disease OccurrenceViral EpidemiologyChildhood Respiratory Syncytial Virus EpidemiologyPcr-based DetectionRespiratory Virus SurveillanceSeasonal Disease VariationSeasonal Respiratory Infection PatternsSeasonality DetectionSeasonality Of Respiratory InfectionsSeasonality Of Viral Infection
During July 2007-June 2015, we enrolled 4,225 hospitalized children with pneumonia in a study to determine the seasonality of respiratory syncytial virus (RSV) infection in Beijing, China. We defined season as the period during which >10% of total PCRs performed each week were RSV positive. We identified 8 distinctive RSV seasons. On average, the season onset occurred at week 41 (mid-October) and lasted 33 weeks, through week 20 of the next year (mid-May); 97% of all RSV-positive cases occurred during the season. RSV seasons occurred 3-5 weeks earlier and lasted ≈6 weeks longer in RSV subgroup A-dominant years than in RSV subgroup B-dominant years. Our analysis indicates that monitoring such RSV subgroup shifts might provide better estimates for the onset of RSV transmission. PCR-based tests could be a flexible or complementary way of determining RSV seasonality in locations where RSV surveillance is less well-established, such as local hospitals throughout China.
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Community-Acquired Pneumonia Requiring Hospitalization among U.S. Children
Seema Jain, Derek J. Williams, Sandra R. Arnold et al. · New England Journal of Medicine · 2015 · 1.8K citations · Full text