Tropical Medicine and Infectious Disease · 2019 · 22 citations · 10 references
Disease ManagementTb TransmissionTuberculosis PreventionPreventive MedicineGlobal Health ProgramPreventive TreatmentPublic HealthPulmonary TuberculosisTuberculosis ControlHealth PolicyEpidemiological OutcomeTuberculosisEpidemiologyGlobal HealthInternational HealthHealth BurdenMedicineTb EpidemicHealth Informatics
The tuberculosis (TB) health burden in Fiji has been declining in recent years, although challenges remain in improving control of the diabetes co-epidemic and achieving adequate case detection across the widely dispersed archipelago. We applied a mathematical model of TB transmission to the TB epidemic in Fiji that captured the historical reality over several decades, including age stratification, diabetes, varying disease manifestations, and incorrect diagnoses. Next, we simulated six intervention scenarios that are under consideration by the Fiji National Tuberculosis Program. Our findings show that the interventions were able to achieve only modest improvements in disease burden, with awareness raising being the most effective intervention to reduce TB incidence, and treatment support yielding the highest impact on mortality. These improvements would fall far short of the ambitious targets that have been set by the country, and could easily be derailed by moderate increases in the diabetes burden. Furthermore, the effectiveness of the interventions was limited by the extensive pool of latent TB infection, because the programs were directed at only active cases, and thus were unlikely to achieve the desired reductions in burden. Therefore, it is essential to address the co-epidemic of diabetes and treat people with latent TB infection.
10
Monte Carlo sampling methods using Markov chains and their applications
W. Keith Hastings · Biometrika · 1970 · 14.9K citations
Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases
Joël Mossong, Niel Hens, Mark Jit et al. · PLoS Medicine · 2008 · 3.1K citations · Full text
Catharina Boehme, Mark P. Nicol, Pamela Nabeta et al. · The Lancet · 2011 · 1K citations · Full text
Xpert Mtb/rif Test, Point-of-care Testing, Pulmonary Tuberculosis +13
Elizabeth L. Corbett, Tsitsi Bandason, Trinh Duong et al. · The Lancet · 2010 · 247 citations · Full text
Disease Diagnosis, Pulmonary Tuberculosis, Cluster-randomised Trial +9
Sylla Thiam, Andrea M. LeFevre, Fatoumata Hane et al. · JAMA · 2007 · 168 citations · Full text