Chemical Science · 2019 · 137 citations · 52 references
PharmacyCancer BiologyOncologyChemotherapyDrug DeliveryNanoparticle Drug DeliveryCancer NanomedicineCombination ChemotherapyNanomaterials For Drug DeliveryNanomedicineNanoparticle DesignTheranostic NanoparticlesCancer NanotherapyHypoxia-driven Therapy ResistanceHypoxia-mediated ResistanceNanoparticle-based ChemotherapyOxygen Consumption In TumorsTumor Microenvironment HypoxiaTumor OxygenationTumor-targeted Drug Delivery
conditions. Furthermore, the F/DOX nanoparticles are favorable for imaging-guided tumor therapy due to the inherent fluorescence properties of IR780. We thus believe that the synergistic treatment described here leads to an ideal therapeutic approach to hypoxic tumors.
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Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.
Katrina M. Comerford, Timothy J. Wallace, Jörn Karhausen et al. · PubMed · 2002 · 844 citations
Medicine, Oncology, Pharmacology +16
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