Dermatologic Therapy · 2019 · 29 citations · 8 references
AsthmaAllergy MedicineSkin AllergyDermatologyMulticentric SeriesInflammatory ArthritisDrug HypersensitivityDupilumab TreatmentClinical EpidemiologyClinical TrialsContact DermatitisRheumatologyAllergyAutoimmune DiseaseClinical DermatologyEffectiveness ResultsSclerodermaMulticentric StudyAtopic DermatitisSystemic TreatmentFood AllergiesMedicineClinical Allergy
Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where immune system disorders and epidermal barrier dysfunction are added to the influence of genetic and environmental factors. Dupilumab has been approved by United States and the European Union regulatory agencies in 2017 for the treatment of moderate-to-severe AD in adult patients who are candidates for systemic treatment. In this short report, we present a retrospective, multicentric study, in which five hospitals in Andalusia, Spain, have taken part. Our objective is to evaluate the safety and effectiveness of dupilumab in patients with moderate-to-severe AD treated with dupilumab with at least 52 weeks of follow-up.
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson, Thomas Bieber, Emma Guttman‐Yassky et al. · New England Journal of Medicine · 2016 · 2K citations · Full text
Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
Lisa A. Beck, Diamant Thaçi, Jennifer D. Hamilton et al. · New England Journal of Medicine · 2014 · 1.4K citations
Andrew Blauvelt, Marjolein de Bruin‐Weller, Melinda Gooderham et al. · The Lancet · 2017 · 1.2K citations · Full text
Diamant Thaçi, Eric L. Simpson, Lisa A. Beck et al. · The Lancet · 2015 · 560 citations