NOP-Related Mechanisms in Substance Use Disorders

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Jean‐Claude Meunier, Catherine Mollereau, Lawrence Toll et al. · Nature · 1995 · 1.9K citations · Full text

Molecular Pharmacology, Endogenous Agonist, Functional Selectivity +8

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

Rainer K. Reinscheid, Hans‐Peter Nothacker, Anne Bourson et al. · Science · 1995 · 1.8K citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

Francesco E. Pontieri, Gianluigi Tanda, Francesco Orzi et al. · Nature · 1996 · 1.1K citations

Substance Abuse, Addictive Drugs, Psychoactive Drug +11

1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial

Johan Kakko, Kerstin Svanborg, Mary Jeanne Kreek et al. · The Lancet · 2003 · 473 citations

Substance Use, Mental Health, Drug Treatment +16