Concepedia

Inactivation of Polymyxin by Hydrolytic Mechanism

Jianhua Yin, Gang Wang, Dan Cheng, Jianv Fu, Juanping Qiu, Zhiliang Yu

Antimicrobial Agents and Chemotherapy · 2019 · 23 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

It is noteworthy that two peptidases S8 from Gram-negative bacteria shared high levels of sequence identity with Apr. Our results indicate that polymyxin resistance may result from inactivation of antibiotics by hydrolysis.

References

25

PmrA–PmrB‐regulated genes necessary for 4‐aminoarabinose lipid A modification and polymyxin resistance

John S. Gunn, Kheng B. Lim, Jackie Krueger et al. · Molecular Microbiology · 1998 · 661 citations

, , +17

<i>Klebsiella pneumoniae</i> AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence

Emma Padilla, Enrique Llobet, Antonio Doménech‐Sánchez et al. · Antimicrobial Agents and Chemotherapy · 2009 · 418 citations · Full text

, , +17

A PhoP-Regulated Outer Membrane Protease of <i>Salmonella enterica</i> Serovar Typhimurium Promotes Resistance to Alpha-Helical Antimicrobial Peptides

Tína Guina, Eugene C. Yi, Houle Wang et al. · Journal of Bacteriology · 2000 · 315 citations · Full text

, , +17

PhoQ Mutations Promote Lipid A Modification and Polymyxin Resistance of Pseudomonas aeruginosa Found in Colistin-Treated Cystic Fibrosis Patients

Amanda Miller, Mark K. Brannon, Laurel Stevens et al. · Antimicrobial Agents and Chemotherapy · 2011 · 224 citations · Full text

, , +17

High osmolarity improves the electro-transformation efficiency of the gram-positive bacteria Bacillus subtilis and Bacillus licheniformis

Gang‐Ping Xue, Jennifer Johnson, Brian P. Dalrymple · Journal of Microbiological Methods · 1999 · 222 citations

, , +8