Concepedia

Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy

Sitong Du, Chao Li, Yiping Lu, Xue Lei, Yiting Zhang, Siyi Li, Fangwei Liu, Ying Chen, Dong Weng, Jie Chen

Theranostics · 2019 · 239 citations · 39 references

DOIFull text

Open access

Concepts

Abstract

Dioscin promoting autophagy leads to reduced CS-induced mitochondria-dependent apoptosis and cytokine production in AMs, which may provide concrete molecular mechanism for the therapy of silicosis.

References

39

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhenyu Zhong, Atsushi Umemura, Elsa Sánchez‐López et al. · Cell · 2016 · 1.2K citations · Full text

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Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Alexander V. Misharin, Luisa Morales‐Nebreda, Paul A. Reyfman et al. · The Journal of Experimental Medicine · 2017 · 1.1K citations · Full text

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Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

Jennifer L. Larson‐Casey, Jessy S. Deshane, Alan J. Ryan et al. · Immunity · 2016 · 422 citations · Full text

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Blockade of IL-6 <i>Trans</i> Signaling Attenuates Pulmonary Fibrosis

Thanh‐Thuy T. Le, Harry Karmouty‐Quintana, Ernestina Melicoff et al. · The Journal of Immunology · 2014 · 302 citations · Full text

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Macrophage autophagy protects against liver fibrosis in mice

Jasper Lodder, Timothé Denaës, Marie-Noële Chobert et al. · Autophagy · 2015 · 260 citations · Full text

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