Effect of tetrahedral DNA nanostructures on proliferation and osteogenic differentiation of human periodontal ligament stem cells

Abstract

Tetrahedral DNA nanostructure treatment facilitated the proliferation of PDLSCs, significantly promoted osteogenic differentiation by regulating the Wnt/β-catenin signalling pathway. Therefore, TDNs could be a novel nanomaterial with great potential for application to PDLSC-based bone tissue engineering.