Concepedia

Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells

Claire Gourzonès, Céline Bellanger, Sylvain Lamure, Ouissem Karmous Gadacha, Elvira Garcia De Paco, Laure Vincent, Guillaume Cartron, Bernard Klein, Jérôme Moreaux

Cancers · 2019 · 30 citations · 47 references

DOIFull text

Open access

Abstract

Our data demonstrate that antioxidant defenses confers resistance to high dose melphalan in MM cells, supporting that redox status in MM cells could be determinant for patients' response to melphalan.

References

47

Bioconductor: open software development for computational biology and bioinformatics

Robert Gentleman, Vincent J. Carey, Douglas M. Bates et al. · Genome biology · 2004 · 12.4K citations · Full text

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

Jawed Alam, Daniel P. Stewart, Cheri Touchard et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase <sub>1</sub>  gene

Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences · 1996 · 1K citations · Full text

Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy

Giuseppina Barrera · ISRN Oncology · 2012 · 803 citations · Full text

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Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

Rossella Marullo, Erica Werner, Natalya Degtyareva et al. · PLoS ONE · 2013 · 761 citations · Full text

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