First Detection of Colistin-Resistant <i>Klebsiella pneumoniae</i> in Association with <i>NDM-5</i> Carbapenemase Isolated from Clinical Lebanese Patients

Abstract

This study aims to describe the molecular mechanisms of carbapenem and colistin resistance in <i>Klebsiella pneumoniae</i> strains isolated from hospitalized patients in Lebanon. We report in this study the first description of <i>NDM-5</i> producing carbapenem-resistant <i>K. pneumoniae</i> ST383, as well as the presence of two out of five isolates resistant to colistin due to mutations in the amino acid sequences of proteins (<i>PmrB</i>, <i>PhoQ</i>, and <i>MgrB</i>). Therefore, screening of such isolates may be effective in limiting the spread of these resistant microorganisms in hospitalized patients and within the community.