A High-Fat/High-Sucrose Diet Induces WNT4 Expression in Mouse Pancreatic β-cells

Abstract

We demonstrated that the HF/HS diet-induced increase of WNT4 signaling in β-cells is involved in augmentation of glucose-induced insulin secretion and impaired β-cell proliferation. These results strongly indicate an essential role of WNT4 in the regulation of β-cell functions in mouse pancreatic islets.