Concepedia

Secondary amines as coupling partners in direct catalytic asymmetric reductive amination

Zitong Wu, Shaozhi Du, Guorui Gao, Yang Wen-kun, Xiongyu Yang, Haizhou Huang, Mingxin Chang

Chemical Science · 2019 · 62 citations · 48 references

DOIFull text

Open access

Concepts

Abstract

Direct asymmetric reductive amination utilizing secondary amines as an efficient tool for one-step construction of tertiary chiral amines.

References

48

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Stephen D. Roughley, Allan M. Jordan · Journal of Medicinal Chemistry · 2011 · 2.7K citations

, , +7

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff et al. · Science · 2010 · 1.7K citations

, , +16

Chiral Amine Synthesis – Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

Thomas C. Nugent, Mohamed El‐Shazly · Advanced Synthesis & Catalysis · 2010 · 887 citations

, , +11

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

Rajenahally V. Jagadeesh, Kathiravan Murugesan, Ahmad S. Alshammari et al. · Science · 2017 · 765 citations

, , +17

Enantioselective Organocatalytic Reductive Amination

Richard Storer, Diane E. Carrera, Yike Ni et al. · Journal of the American Chemical Society · 2005 · 731 citations

, , +15