mBio · 2019 · 55 citations · 41 references
Life SciencesGeneticsMicrobiologyBacteriologyHost-pathogen InteractionsMicrobial PathogenesisBacterial PathogenesisBacteriophage GeneticsHost Defense Against InfectionHost-microbe InteractionsPathogen RecognitionPhage GeneticsHost Defense Against Bacterial InfectionImmune Escape MutationsPhage Defense EvasionPhage Host SpecificityPhage InfectionPhage Repressor ProteinsPhage-host InteractionsTemperate Phage Biology
Prophage-mediated viral defense systems play a key role in microbial dynamics, as lysogeny is established relatively efficiently, and prophage-expressed genes can strongly inhibit lytic infection of other, unrelated phages. Demonstrating such defense systems in Gordonia terrae suggests that these systems are widespread and that there are a multitude of different systems with different specificities for the attacking phages.
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Systematic discovery of antiphage defense systems in the microbial pangenome
Shany Doron, Sarah Melamed, Gal Ofir et al. · Science · 2018 · 1.4K citations · Full text
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
Joe Bondy-Denomy, April Pawluk, Karen L. Maxwell et al. · Nature · 2012 · 861 citations · Full text