Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 induction is ideal for influenza

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi et al. · Science · 2004 · 3.4K citations

Life Sciences, Immunology, Molecular Biology +17

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

Menno D. de Jong, Cameron P. Simmons, Tran Tan Thanh et al. · Nature Medicine · 2006 · 1.9K citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +11

Recognition of single-stranded RNA viruses by Toll-like receptor 7

Jennifer M. Lund, Lena Alexopoulou, Ayuko Sato et al. · Proceedings of the National Academy of Sciences · 2004 · 1.8K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.

Frederick G. Hayden, Roschelle Fritz, M C Lobo et al. · Journal of Clinical Investigation · 1998 · 684 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever

Kanato Yamagata, Kiyoshi Matsumura, Wataru Inoue et al. · Journal of Neuroscience · 2001 · 374 citations · Full text

Life Sciences, Neurobiology, Neuroscience +13