Concepedia

Publication | Open Access

<i>SMPD1</i> mutations, activity, and α‐synuclein accumulation in Parkinson's disease

DOIFull Paper Access

110

Citations

24

References

2019

Year

Roy N. Alcalay, Victoria Mallett, Benoît Vanderperre, Omid Tavassoly, Yves Dauvilliers, Richard Y. J. Wu, Jennifer A. Ruskey, Claire S. Leblond, Amirthagowri Ambalavanan, Sandra B. Laurent,
Movement Disorders

Abstract

Our results support an association between SMPD1 variants, acid-sphingomyelinase activity, and PD. Furthermore, they suggest that reduced acid-sphingomyelinase activity may lead to α-synuclein accumulation. © 2019 International Parkinson and Movement Disorder Society.

References

YearCitations

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