Concepedia

NR4A transcription factors limit CAR T cell function in solid tumours

Joyce Chen, Isaac F. López-Moyado, Hyungseok Seo, Chan‐Wang Jerry Lio, Laura J. Hempleman, Takashi Sekiya, Akihiko Yoshimura, James Scott‐Browne, Anjana Rao

Nature · 2019 · 853 citations · 43 references

Open access

Concepts

Life SciencesMolecular BiologyOncologyCancer ImmunologyMolecular OncologyTumor ImmunologyCancer Cell SignalingT Cell BiologyT Cell DifferentiationT Cell ExhaustionT Cell Responses To TumorsTranscription FactorsCar T-cell ExhaustionCd4+ Tumor-infiltrating LymphocytesHelper T Cell DifferentiationSolid Tumor Car T-cell TherapyTranscriptional Regulation Of T Cell DifferentiationTumor-specific T Cell Activation

References

43

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

Life Sciences, Bioinformatics, Biostatistics +15

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 56.7K citations · Full text

Life Sciences, Bioinformatics, Oncology +12

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin, Carrie Davis, Felix Schlesinger et al. · Bioinformatics · 2012 · 56.2K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu et al. · Nucleic Acids Research · 2015 · 43K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead, Cole Trapnell, Mihai Pop et al. · Genome biology · 2009 · 23K citations · Full text

Life Sciences, Bioinformatics, High-performance Computing +15