Uncatalyzed, on water oxygenative cleavage of inert C–N bond with concomitant 8,7-amino shift in 8-aminoquinoline derivatives

Abstract

Oxygenative cleavage of an inert C_Ar–NH₂ bond with concomitant 1,2 amine migration in 8-aminoquinoline derivatives is achieved through an efficient, catalyst free, one step synthesis of 8-benzyloxy, 7-aminoquinoline directly from 8-aminoquinoline in water at room temperature.