Comparison of Biomarker Assays for <i>EGFR</i> : Implications for Precision Medicine in Patients with Glioblastoma

Abstract

Methods for assessing <i>EGFR</i> mRNA expression (RT-PCR, RNAseq) and copy number (WES), but not protein expression (IHC), can be used as surrogates for <i>EGFR</i> amplification (FISH) in GBM. Collectively, our results provide enhanced understanding of available screening options for patients, which may help guide EGFR-targeted therapeutic approaches.