Concepedia

Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds

Omidreza Firuzi, Fernanda Borges, Alexandra Gaspar, Maryam Mohabbati, Fernando Cagide, Nima Razzaghi‐Asl, Ramin Miri

Research in Pharmaceutical Sciences · 2019 · 18 citations · 24 references

DOIFull text

Open access

Concepts

Abstract

, 68.4 ± 3.9 μM). In conclusion, this study provides important information on the cytotoxic effects of chromone derivatives. Benzochroman-2,4-dione has been identified as a promising scaffold, which its potency can be modulated by tailored synthesis with the aim of finding novel and dissimilar anticancer compounds.

References

24

Chromone, a Privileged Scaffold for the Development of Monoamine Oxidase Inhibitors

Alexandra Gaspar, Tiago Silva, Matilde Yáñez et al. · Journal of Medicinal Chemistry · 2011 · 143 citations · Full text

, , +16

Synthesis, structure–activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents

B. China Raju, R. Nageswara Rao, Pathi Suman et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 109 citations

, , +14

Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents

Mohan Paul S. Ishar, Gurpinder Singh, Satyajit Singh et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 89 citations

, , +8

Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: Identification of a lead for anti-inflammatory drug

Shaveta Shaveta, Matinder Kaur, Surbhi Sharma et al. · European Journal of Medicinal Chemistry · 2014 · 81 citations · Full text

, , +14

Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors

Alexandra Gaspar, Joana Reis, André Fonseca et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 81 citations · Full text

, , +7