Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data

Variance component model to account for sample structure in genome-wide association studies

Hyun Min Kang, Jae Hoon Sul, Susan K. Service et al. · Nature Genetics · 2010 · 3K citations · Full text

Genome-wide Association Study, Genetic Analysis, Variance Component Model +12

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

Michael C. Wu, Seunggeun Lee, Tianxi Cai et al. · The American Journal of Human Genetics · 2011 · 2.5K citations · Full text

Bioinformatics, Genome-wide Association Study, Medicine +12

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Nature · 2011 · 2K citations · Full text

Hypertension, Genetic Variants, Allelic Variant +10

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

Bingshan Li, Suzanne M. Leal · The American Journal of Human Genetics · 2008 · 1.6K citations · Full text

Genome-wide Association Study, Rare Variants, Genotype-phenotype Association +11

Genome-wide association study of blood pressure and hypertension

Daniel Levy, Georg Ehret, Kenneth Rice et al. · Nature Genetics · 2009 · 1.4K citations · Full text

Genome-wide Association Study, Hypertension, Epidemiology +8