Concepedia

Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

Roberta Fraioli, Stefanie Neubauer, Florian Rechenmacher, Begoña M. Bosch, Khandmaa Dashnyam, J.-H. Kim, Román A. Pérez, Hae‐Won Kim, F.J. Gil, Maria‐Pau Ginebra,

Biomaterials Science · 2019 · 21 citations · 31 references

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Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

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Clustering of α <sub>5</sub> β <sub>1</sub> integrins determines adhesion strength whereas α <sub>v</sub> β <sub>3</sub> and talin enable mechanotransduction

Pere Roca‐Cusachs, Nils C. Gauthier, Armando E. del Río Hernández et al. · Proceedings of the National Academy of Sciences · 2009 · 415 citations · Full text