Concepedia

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

Kenneth M. Boy, Jason Guernon, Dmitry Zuev, Li Xu, Yunhui Zhang, Jianliang Shi, Lawrence R. Marcin, Mendi A. Higgins, Yong‐Jin Wu, Subramaniam Krishnananthan,

ACS Medicinal Chemistry Letters · 2019 · 22 citations · 18 references

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Abstract

produced. No Notch-based toxicity was observed, and the overall preclinical profile of BMS-932481 supported its further evaluation in human clinical trials.

References

18

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron · 2003 · 4.1K citations · Full text

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2018 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2018 · 1.9K citations

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Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

Travis T. Wager, Xinjun Hou, Patrick R. Verhoest et al. · ACS Chemical Neuroscience · 2010 · 1K citations

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Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

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Comparison of four basic models of indirect pharmacodynamic responses

Natalie Dayneka, Varun Garg, William J. Jusko · Journal of Pharmacokinetics and Biopharmaceutics · 1993 · 811 citations

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