MAPK Inhibitors Enhance HDAC Inhibitor-Induced Redifferentiation in Papillary Thyroid Cancer Cells Harboring BRAFV600E: An In Vitro Study

Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer

Alan L. Ho, Ravinder K. Grewal, Rébecca Leboeuf et al. · New England Journal of Medicine · 2013 · 829 citations · Full text

Medicine, Endocrinology, Nuclear Medicine +16

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

Debyani Chakravarty, Elmer Santos, Mabel Ryder et al. · Journal of Clinical Investigation · 2011 · 387 citations

Medicine, Oncology, Pharmacology +17

Redifferentiation of Iodine-Refractory <i>BRAF</i> V600E-Mutant Metastatic Papillary Thyroid Cancer with Dabrafenib

S. Michael Rothenberg, David G. McFadden, Edwin L. Palmer et al. · Clinical Cancer Research · 2014 · 367 citations

Medicine, Oncology, Pharmacotherapy +17

Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma

Hendrieke C. Hoftijzer, Karen A. Heemstra, Hans Morreau et al. · European Journal of Endocrinology · 2009 · 239 citations

Medicine, Oncology, Pharmacology +16

Suppression of BRAF/MEK/MAP Kinase Pathway Restores Expression of Iodide-Metabolizing Genes in Thyroid Cells Expressing the V600E BRAF Mutant

Dingxie Liu, Shuiying Hu, Peng Hou et al. · Clinical Cancer Research · 2007 · 198 citations

Medicine, Oncology, Epigenetics +12